Sina Mansour L.

Sina Mansour L.

Network science enthusiast admiring the brain 🧠,
Postdoctoral Research Fellow
Computational Brain Imaging Group, National University of Singapore, and
MNC Systems lab,
The University of Melbourne

Functional dedifferentiation of the brain during healthy aging

Published in Journal of neurophysiology, 2020

Recommended citation: Rakesh, Divyangana, Kavisha B. Fernando, and Sina Mansour L. "Functional dedifferentiation of the brain during healthy aging." Journal of neurophysiology 123.4 (2020): 1279-1282. https://doi.org/10.1152/jn.00039.2020

Article available from here.

Abstract:

Nonpathological aging is associated with significant cognitive deficits. Thus, the underlying neurobiology of aging-associated cognitive decline warrants investigation. In a recent study, Chong et al. (Chong JSX, Ng KK, Tandi J, Wang C, Poh J-H, Lo JC, Chee MWL, Zhou JH. J Neurosci 39: 5534–5550, 2019) provided insights into the association between cognitive decline and the loss of functional specialization in the brains of older adults. Here, we introduce the novel graph theoretical approach utilized and discuss the significance of their findings and broader implications on aging. We also provide alternate perspectives of their findings and suggest directions for future work.