ABNORMAL BRAIN AGING IN YOUTH WITH SUBCLINICAL PSYCHOSIS AND OBSESSIVE-COMPULSIVE SYMPTOMS

Published in Schizophrenia Bulletin, 2020

Recommended citation: Cropley, Vanessa, et al. "O2. 3. ABNORMAL BRAIN AGING IN YOUTH WITH SUBCLINICAL PSYCHOSIS AND OBSESSIVE-COMPULSIVE SYMPTOMS." Schizophrenia Bulletin 46.Suppl 1 (2020): S4. https://doi.org/10.1093/schbul/sbaa028.008

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Abstract:

Psychiatric symptoms in childhood and adolescence have been associated with both delayed and accelerated patterns of grey matter development. This suggests that deviation in brain structure from a normative range of variation for a given age might be important in the emergence of psychopathology. Distinct from chronological age, brain age refers to the age of an individual that is inferred from a normative model of brain structure for individuals of the same age and sex. We predicted brain age from a common set of grey matter features and examined whether the difference between an individual’s chronological and brain age was associated with the severity of psychopathology in children and adolescents.